Epidermal Growth Factor Receptor/EGFR Ab-5 Mouse Monoclonal Antibody, Epredia™

Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, immunoprecipitation and flow cytometry experiments.

Brand:  Epredia MS-316-P1

Product Code. 12650977

Description

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: H11

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: Extracellular domain

Immunogen: HC2 20 d2 cells

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells, Placenta or Squamous cell CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence
• Immunoprecipitation (Native only)
• Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Epidermal Growth Factor Receptor/EGFR Ab-5
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Research Discipline: EGFR Family
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: H11
• Conjugate: Unconjugated
• Immunogen: HC2 20 d2 cells
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated