Estrone, 99+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity	Packaging
10764031	Thermo Scientific Acros 117840010	1 g	Glass bottle
10694762	Thermo Scientific Acros 117840050	5 g	Glass bottle
11976881	Thermo Scientific Acros 117840250	25 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Estrone is an aromatized C18 steroid considered one of the major mammalian estrogen and a sex hormone. It shows antineoplastic and bone density conservative activities.

• This compound can interact with estrogen receptors in target tissues to produce similar effects to estradiol. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes.

Applications

• Estrone has the ability to increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins.

• It can suppress the release of follicle-stimulating hormone and luteinizing hormone.

• This compound can be produced from androstenedione or testosterone via estradiol. In vivo, it can be generated mainly in the ovaries, placenta, and peripheral tissues (especially adipose tissue) through conversion of androstenedione. It may be metabolized to 16-α-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.

• It has been used as medium supplement for hormone-based degranulation studies of natural killer cells.

• It is used as medium component for monitoring fatty acid synthase activity in breast adenocarcinoma cell lines.

Chemical Identifiers

• CAS: 53-16-7
• Molecular Weight (g/mol): 270.36
• Synonym: estrone, folliculin, oestrone, theelin, estrovarin, estrugenone, follicular hormone, kestrone, estron, follicunodis
• ChEBI: CHEBI:17263
• SMILES: CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O

• Molecular Formula: C₁₈H₂₂O₂
• InChI Key: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• PubChem CID: 5870
• IUPAC Name: (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

Specifications

• CAS: 53-16-7
• Color: White
• Infrared Spectrum: Authentic
• Molecular Formula: C₁₈H₂₂O₂
• Specific Rotation Condition: + 158.00 (20.00°C c=1,dioxane)
• Synonym: estrone, folliculin, oestrone, theelin, estrovarin, estrugenone, follicular hormone, kestrone, estron, follicunodis
• InChI Key: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• IUPAC Name: (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
• PubChem CID: 5870
• Formula Weight: 270.36
• Percent Purity: 99+%
• Chemical Name or Material: Estrone

• Melting Point: 258.0°C to 261.0°C
• Loss on Drying: 0.5% max. (105°C, 3 hrs)
• Assay Percent Range: 99% min. (on dried substance) (HPLC)
• Merck Index: 15,3763
• Specific Rotation: + 158.00
• Solubility Information: Solubility in water: 0.03g/L.
• SMILES: CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
• Molecular Weight (g/mol): 270.36
• ChEBI: CHEBI:17263
• Clarity: passes test
• Physical Form: Crystalline Powder or Crystals

Safety and Handling

GHS H Statement:
Harmful if swallowed.
Suspected of causing cancer.
Harmful in contact with skin.
May cause an allergic skin reaction.
Harmful if inhaled.
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Suspected of damaging fertility.

GHS P Statement:
Wear protective gloves/protective clothing/eye protection/face protection.
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Wear eye protection/face protection.
Use personal protective equipment as required.
IF ON SKIN: Wash with plenty of soap and water.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Danger

missing translation for 'einecsNumber' : 200-164-5

Product Identifier

• Estrone

Signal Word

• Danger

Hazard Category

• Carcinogenicity Category 2
• Reproductive toxicity on or via lactation
• Reproductive toxicity Category 1A

Hazard Statement

• H351-Suspected of causing cancer.
• H360FD-May damage fertility. May damage the unborn child.
• H362-May cause harm to breast-fed children.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only