Estrone, 99+%, Thermo Scientific Chemicals

Description

Estrone, 99%, CAS#53-16-7, is one of the major mammalian estrogen, is a steroid and a sex hormone. It is synthetized from cholesterol and secreted mainly from the gonads. It also presents antineoplastic and bone density conservative activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Estrone is an aromatized C18 steroid considered one of the major mammalian estrogen and a sex hormone. It shows antineoplastic and bone density conservative activities.

• This compound can interact with estrogen receptors in target tissues to produce similar effects to estradiol. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes.

Applications

• Estrone has the ability to increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins.

• It can suppress the release of follicle-stimulating hormone and luteinizing hormone.

• This compound can be produced from androstenedione or testosterone via estradiol. In vivo, it can be generated mainly in the ovaries, placenta, and peripheral tissues (especially adipose tissue) through conversion of androstenedione. It may be metabolized to 16-α-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.

• It has been used as medium supplement for hormone-based degranulation studies of natural killer cells.

• It is used as medium component for monitoring fatty acid synthase activity in breast adenocarcinoma cell lines.

Specifications

Chemical Identifiers

• CAS: 53-16-7
• Molecular Formula: C₁₈H₂₂O₂
• Molecular Weight (g/mol): 270.36
• InChI Key: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Synonym: estrone, folliculin, oestrone, theelin, estrovarin, estrugenone, follicular hormone, kestrone, estron, follicunodis
• PubChem CID: 5870
• ChEBI: CHEBI:17263
• IUPAC Name: (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
• SMILES: CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O

• Melting Point: 258.0°C to 261.0°C
• Color: White
• Loss on Drying: 0.5% max. (105°C, 3 hrs)
• Infrared Spectrum: Authentic
• Assay Percent Range: 99% min. (on dried substance) (HPLC)
• Packaging: Glass bottle
• Quantity: 5 g
• Merck Index: 15,3763
• Specific Rotation Condition: + 158.00 (20.00°C c=1,dioxane)
• Specific Rotation: + 158.00
• Solubility Information: Solubility in water: 0.03g/L.
• Formula Weight: 270.36
• Clarity: passes test
• Percent Purity: 99+%
• Physical Form: Crystalline Powder or Crystals
• Chemical Name or Material: Estrone

Safety and Handling

Product Identifier

• Estrone

Signal Word

• Danger

Hazard Category

• Carcinogenicity Category 2
• Reproductive toxicity on or via lactation
• Reproductive toxicity Category 1A

Hazard Statement

• H351-Suspected of causing cancer.
• H360FD-May damage fertility. May damage the unborn child.
• H362-May cause harm to breast-fed children.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only