Ethyl 4-chloroacetoacetate, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11447547	Thermo Scientific Alfa Aesar A15641.18	50 g
11457547	Thermo Scientific Alfa Aesar A15641.30	250 g
11437547	Thermo Scientific Alfa Aesar A15641.0B	1000 g

Description

Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Ethyl 4-chloroacetoacetate is used as a precursor in the preparation of phosphorous ylides. It finds application in regular film coating, pharmaceutical coating and formulation.

Solubility
Miscible with water and most organic solvents.

Notes
Incompatible with strong acids, strong bases, reducing agents and strong oxidizing agents. Store in a cool place.

Chemical Identifiers

• CAS: 638-07-3
• Molecular Weight (g/mol): 164.585
• InChI Key: OHLRLMWUFVDREV-UHFFFAOYSA-N
• PubChem CID: 69484
• SMILES: CCOC(=O)CC(=O)CCl

• Molecular Formula: C6H9ClO3
• MDL Number: MFCD00000939
• Synonym: ethyl 4-chloroacetoacetate, 4-chloroacetoacetic acid ethyl ester, butanoic acid, 4-chloro-3-oxo-, ethyl ester, ethyl gamma-chloroacetoacetate, unii-5ae82250cm, ccris 6791, ethyl chloroacetyl acetate, butanoic acid, 4-chloro-3-oxo-ethylester, ethyl 4-chloro-3-oxobutyrate, ethyl 4-chloro-3-oxo-butanoate
• IUPAC Name: ethyl 4-chloro-3-oxobutanoate

Specifications

• CAS: 638-07-3
• Density: 1.212
• Flash Point: 92°C (198°F)
• Refractive Index: 1.452
• UN Number: UN2922
• Synonym: ethyl 4-chloroacetoacetate, 4-chloroacetoacetic acid ethyl ester, butanoic acid, 4-chloro-3-oxo-, ethyl ester, ethyl gamma-chloroacetoacetate, unii-5ae82250cm, ccris 6791, ethyl chloroacetyl acetate, butanoic acid, 4-chloro-3-oxo-ethylester, ethyl 4-chloro-3-oxobutyrate, ethyl 4-chloro-3-oxo-butanoate
• InChI Key: OHLRLMWUFVDREV-UHFFFAOYSA-N
• IUPAC Name: ethyl 4-chloro-3-oxobutanoate
• PubChem CID: 69484
• Percent Purity: 97%

• Melting Point: -8°C
• Boiling Point: 220°C
• Molecular Formula: C6H9ClO3
• MDL Number: MFCD00000939
• Beilstein: 1761275
• Solubility Information: Miscible with water and most organic solvents.
• SMILES: CCOC(=O)CC(=O)CCl
• Molecular Weight (g/mol): 164.585
• Formula Weight: 164.59
• Chemical Name or Material: Ethyl 4-chloroacetoacetate

Safety and Handling

GHS H Statement
H301-H314-H318-H227
Toxic if swallowed.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Combustible liquid.

P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

H301+H311-H314-H335

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Recommended Storage : Ambient temperatures

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 2
• Acute toxicity Category 3
• LONG-TERM AQUATIC HAZARD Chronic 2
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B
• Skin sensitiser Category 1

Hazard Statement

• H301-Toxic if swallowed.
• H310-Fatal in contact with skin.
• H314-Causes severe skin burns and eye damage.
• H317-May cause an allergic skin reaction.
• H318-Causes serious eye damage.
• H411-Toxic to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.
• P362+P364-Take off contaminated clothing and wash it before reuse.

RUO – Research Use Only