Ethyl propiolate, 99%, Thermo Scientific Chemicals

Description

Ethyl propiolate is used as a precursor in the preparation of substituted anthraquinones and pyrazolo[1,5-a]pyridine, which exhibits anti-inflammatory activity. Further, it is employed in the synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Its halogenated derivatives are used as a substrate for direct, asymmetric alkynylation of cyclic beta-ketoesters using chiral phase-transfer catalysts.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Ethyl propiolate is used as a precursor in the preparation of substituted anthraquinones and pyrazolo[1,5-a]pyridine, which exhibits anti-inflammatory activity. Further, it is employed in the synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Its halogenated derivatives are used as a substrate for direct, asymmetric alkynylation of cyclic beta-ketoesters using chiral phase-transfer catalysts.

Solubility
Miscible with alcohol.

Notes
Incompatible with oxidizing agents, bases and acids.

Specifications

Chemical Identifiers

• CAS: 623-47-2
• Molecular Formula: C5H6O2
• Molecular Weight (g/mol): 98.10
• MDL Number: MFCD00009184
• InChI Key: FMVJYQGSRWVMQV-UHFFFAOYSA-N
• Synonym: ethyl propiolate, ethyl acetylenecarboxylate, 2-propynoic acid, ethyl ester, propiolic acid ethyl ester, ethyl propynoate, ethoxycarbonyl acetylene, ethyl 2-propynoate, propiolic acid, ethyl ester, unii-w235g5u52s, propynoic acid ethyl ester
• PubChem CID: 12182
• ChEBI: CHEBI:51740
• IUPAC Name: ethyl prop-2-ynoate
• SMILES: CCOC(=O)C#C

• Melting Point: 9°C
• Density: 0.963
• Boiling Point: 118°C to 120°C
• Flash Point: 23°C (73°F)
• Odor: Pungent
• Linear Formula: HC≡CCO₂CH₂CH₃
• Refractive Index: 1.412
• Quantity: 5 g
• UN Number: UN3272
• Beilstein: 878250
• Solubility Information: Miscible with alcohol.
• Formula Weight: 98.1
• Percent Purity: 99%
• Chemical Name or Material: Ethyl propiolate

Safety and Handling

Product Identifier

• Ethyl propiolate

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Flammable liquid Category 3
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H226-Flammable liquid and vapour.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P240-Ground/bond container and receiving equipment.
• P242-Use only non-sparking tools.
• P243-Take precautionary measures against static discharge.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P271-Use only outdoors or in a well-ventilated area.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P363-Wash contaminated clothing before reuse.
• P370+P378-In case of fire: Use to extinguish.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Ethyl propiolate

RUO – Research Use Only