Thermo Scientific Chemicals Ethylmercurithiosalicylic acid, sodium salt, 97.0-101.0%

Description

Ethylmercurithiosalicylic acid, CAS # 54-64-8, is an oxidizing reagent that can inhibit various sulfhydryl-dependent enzymes and proteins. It is also known as thimerosal or 2-(ethylmercuriomercapto)benzoic acid sodium salt.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Ethylmercurithiosalicylic acid is an oxidizing reagent that inhibits sulfhydryl-containing active sites of several enzymes
• It is also known as thimerosal or 2-(ethylmercuriomercapto)benzoic acid sodium salt.
• It can bind to sulfhydryl compounds, such as glutathione, cysteine, and sulfhydryl groups of proteins
• Additionally, it can activate inositol triphosphate calcium channels on membranes of the endoplasmic reticulum, resulting in the regulation of cellular functions

Applications

• Ethylmercurithiosalicylic acid has been widely investigated as a preservative in medicinal laboratory research, including vaccine studies
• It has been shown to exhibit antifungal and antiseptic properties

Specifications

Chemical Identifiers

• CAS: 54-64-8
• Molecular Formula: C9H9HgNaO2S
• Molecular Weight (g/mol): 404.81
• MDL Number: MFCD00013062
• InChI Key: RTKIYNMVFMVABJ-UHFFFAOYSA-L
• Synonym: thimerosal, thiomersal, thiomersalate, mercurothiolate, sodium merthiolate, sodium ethylmercurithiosalicylate, merthiolate, thimerosalate, thimerosalum, thimersalate
• PubChem CID: 16684434
• ChEBI: CHEBI:9546
• IUPAC Name: sodium;(2-carboxylatophenyl)sulfanyl-ethylmercury
• SMILES: [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O

• Melting Point: 232.0°C to 233.0°C
• Color: White to Cream
• pH: 6 to 8 (1% soln.)
• Physical Form: Powder
• Quantity: 500 g
• Assay Percent Range: 97.0-101.0%
• Linear Formula: 2-(C₂H₅HgS)C₆H₄CO₂Na
• Flash Point: 250°C
• Merck Index: 15, 9470
• Solubility Information: Solubility in water: 1g/1mL (20°C). Other solubilities: 1g/8mL in alcohol, 1g/10mL in methanol, almost insoluble in ether and benzene
• Formula Weight: 404.8
• Percent Purity: 97.0 to 101%
• Infrared Spectrum: Authentic
• Loss on Drying: 0.5% max. (vacuum/P2O5)
• Packaging: Glass bottle
• Chemical Name or Material: Ethylmercurithiosalicylic acid, sodium salt

Safety and Handling

Product Identifier

• Ethylmercurithiosalicylic acid, sodium salt

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Acute toxicity Category 2
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H300-Fatal if swallowed.
• H310-Fatal in contact with skin.
• H330-Fatal if inhaled.
• H373-May cause damage to organs.
• H400-Very toxic to aquatic life.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P273-Avoid release to the environment.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.

Supplemental information

• MIXTURE LIST-Contains : Sodium o-(ethylmercurithio)benzoate

RUO – Research Use Only