STEMCELL Technologies FK506

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

Product Code	Brand	Quantity
17180332	STEMCELL Technologies 74152	10 mg
17190332	STEMCELL Technologies 74154	50 mg

Description

• FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
• Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
• In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
• Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)

Specifications

• CAS: 104987-11-3
• Synonym: Tacrolimus
• Molecular Formula: C₄₄H₆₉NO₁₂
• Purity: ≥99%