Flavopiridol hydrochloride, Tocris Bioscience™

Description

Cdk inhibitor; potently inhibits cdk2 and cdk9

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.

Specifications

Chemical Identifiers

• CAS: 131740-09-5
• Molecular Formula: C21H21Cl2NO5
• Molecular Weight (g/mol): 438.301
• InChI Key: LGMSNQNWOCSPIK-LWHGMNCYSA-N
• Synonym: flavopiridol hydrochloride, alvocidib hydrochloride, alvocidib hcl, unii-d48ms3a6n9, flavopiridol alvocidib hcl, alvocidib hydrochloride usan, flavopiridol hcl, dsstox_cid_28887, dsstox_rid_83155
• PubChem CID: 9910986
• IUPAC Name: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride
• SMILES: CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

• Quantity: 10 mg
• Formula Weight: 438.3
• Percent Purity: >98%
• Chemical Name or Material: Flavopiridol hydrochloride