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Flavopiridol hydrochloride, Tocris Bioscience™

Product Code. 30001504
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Quantity:
10 mg
50 mg
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Description

Cdk inhibitor; potently inhibits cdk2 and cdk9

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.

Chemical Identifiers

CAS 131740-09-5
Molecular Formula C21H21Cl2NO5
Molecular Weight (g/mol) 438.301
InChI Key LGMSNQNWOCSPIK-LWHGMNCYSA-N
Synonym flavopiridol hydrochloride, alvocidib hydrochloride, alvocidib hcl, unii-d48ms3a6n9, flavopiridol alvocidib hcl, alvocidib hydrochloride usan, flavopiridol hcl, dsstox_cid_28887, dsstox_rid_83155
PubChem CID 9910986
IUPAC Name 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride
SMILES CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Specifications

Quantity 50 mg
Formula Weight 438.3
Percent Purity >98%
Chemical Name or Material Flavopiridol hydrochloride
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