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  6. Fludarabine, Tocris Bioscience™

Fludarabine, Tocris Bioscience™

Catalog Number 18782624
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
21679-14-1
C10H12FN5O4
285.24
MFCD00132942
HBUBKKRHXORPQB-FJFJXFQQSA-N
fludarabine, f-ara-a, 2-fluoro ara-a, 9-beta-d-arabinofuranosyl-2-fluoroadenine, fludarabine inn, fludarabinum latin, fludarabina spanish, fludarabina, fludarabinum, 2r,3s,4s,5r-2-6-amino-2-fluoro-9h-purin-9-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol
657237
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C2=NC(F)=N1
This item is not returnable. View return policy
21679-14-1
C10H12FN5O4
285.24
MFCD00132942
HBUBKKRHXORPQB-FJFJXFQQSA-N
fludarabine, f-ara-a, 2-fluoro ara-a, 9-beta-d-arabinofuranosyl-2-fluoroadenine, fludarabine inn, fludarabinum latin, fludarabina spanish, fludarabina, fludarabinum, 2r,3s,4s,5r-2-6-amino-2-fluoro-9h-purin-9-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol
657237
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C2=NC(F)=N1

Description

Purine analog; inhibits DNA synthesis

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.
Quantity 10 mg
Formula Weight 285.23
Percent Purity >99%
Chemical Name or Material Fludarabine
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