Tocris Bioscience™ FRAX 486

Potent PAK inhibitor; brain penetrant and orally bioavailable

Brand:  Tocris Bioscience™ 5190/10

Product Code. 18711678

Description

FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.

Specifications

• Purity: >98%
• Product Type: FRAX 486
• Inhibitors: FRAX 486

• Quantity: 10 mg
• Molecular Weight (g/mol): 513.39

For Research Use Only