Tocris Bioscience™ FTIDC

Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist

Brand:  Tocris Bioscience™ 5000/10

Product Code. 18701078

Description

FTIDC is a potent and selective mGlu1 receptor negative allosteric modulator (IC50 values are 5.8 and 6200 nM for mGlu1 and mGlu5 respectively). Also acts as an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu1-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.

Specifications

• Purity: >98%
• Product Type: FTIDC
• Inhibitors: FTIDC

• Quantity: 10 mg
• Molecular Weight (g/mol): 358.41

For Research Use Only