G 5555

High affinity group 1 PAK inhibitor

Brand:  Tocris Bioscience 6051/10

Product Code. 18716178

Description

G 5555 is a high affinity group 1 PAK (pan-PAK1, 2 and 3) inhibitor (Ki = 3.7 nM; pMEK IC50 = 69 nM). Of 235 kinases tested, other than PAK1, eight (PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1) were inhibited >70%. Exhibits low hERG channel activity (<50% inhibition at 10 μM). Orally bioavailable.

Specifications

• Chemical Name or Material: 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one
• Assay Percent Range: >98%
• Molecular Formula: C₂₅H_25ClN₆O₃

• CAS: 1648863-90-4
• Quantity: 10 mg
• Formula Weight: Observed MW: 492.96