Gavestinel, Tocris Bioscience™

Description

Potent and selective glycine site antagonist; orally available and active in vivo

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo.

Specifications

Chemical Identifiers

• CAS: 153436-38-5
• Molecular Formula: C18H12Cl2N2NaO3
• Molecular Weight (g/mol): 398.195
• InChI Key: OBPMZHMRJJJUBC-UHDJGPCESA-N
• Synonym: gavestinel
• PubChem CID: 67241466
• IUPAC Name: 3-[(E)-3-anilino-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylic acid;sodium
• SMILES: C1=CC=C(C=C1)NC(=O)C=CC2=C(NC3=CC(=CC(=C32)Cl)Cl)C(=O)O.[Na]

• Quantity: 50 mg
• Formula Weight: 397.19
• Percent Purity: >98%
• Chemical Name or Material: Gavestinel