Gemcitabine hydrochloride, Tocris Bioscience™

Description

DNA synthesis inhibitor

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.

Specifications

Chemical Identifiers

• CAS: 122111-03-9
• Molecular Formula: C9H12ClF2N3O4
• Molecular Weight (g/mol): 299.659
• InChI Key: OKKDEIYWILRZIA-OSZBKLCCSA-N
• Synonym: gemcitabine hcl, 2',2'-difluorodeoxycytidine monohydrochloride, 2'-deoxy-2',2'-difluorocytidine hydrochloride, 2 1h-pyrimidinone, 4-amino-1-2-deoxy-2,2-difluoro-d-erythro-pentofuranosyl
• PubChem CID: 44558863
• ChEBI: CHEBI:31647
• IUPAC Name: 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;chloride
• SMILES: [H+].C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.[Cl-]

• Quantity: 50 mg
• Formula Weight: 299.66
• Percent Purity: >99%
• Chemical Name or Material: Gemcitabine hydrochloride