GI 254023X, Tocris Bioscience™

Description

Selective ADAM10 metalloprotease inhibitor

Selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin shedding in IMPE cells. Prevents E-cadherin cleavage in A549 cells. Inhibits ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro.

Specifications

• CAS: 260264-93-5
• Molecular Formula: C21H33N3O4
• MDL Number: MFCD19381832
• Quantity: 1 mg
• Synonym: 2r-n-1s-2,2-dimethyl-1-methylamino carbonyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r,3s-3-formylhydroxyamino-2-3-phenyl-1-propyl butanoic acid 1s-2,2-dimethyl-1-methylcarbamoyl-1-propyl amide, bidd:pxr0042, gi254023x hplc, 2r-n-1s-2,2-dimethyl-1-methylcarbamoyl propyl-2-1s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxidanylidene-butan-2-yl-2-1s-1-methanoyl oxidanyl amino ethyl-5-phenyl-pentanamide, 2r-n-2s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-1s-1-formyl hydroxy amino ethyl-5-phenylpentanamide, r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-n-hydroxyformamido ethyl-5-phenylpentanamide, gi 254023x r-n-s-3,3-dimethyl-1-methylamino-1-oxobutan-2-yl-2-s-1-nhydroxyformamido
• InChI Key: GHVMTHKJUAOZJP-UHFFFAOYNA-N
• SMILES: CNC(=O)C(NC(=O)C(CCCC1=CC=CC=C1)C(C)N(O)C=O)C(C)(C)C
• IUPAC Name: N-[2,2-dimethyl-1-(methylcarbamoyl)propyl]-2-[1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide
• Molecular Weight (g/mol): 391.51
• PubChem CID: 9952396
• Formula Weight: 391.5
• Percent Purity: >98%
• Chemical Name or Material: GI 254023X