Glibenclamide, Tocris Bioscience™

Description

Kir6 (KATP) channel blocker

ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Specifications

• CAS: 10238-21-8
• Molecular Formula: C23H28ClN3O5S
• Quantity: 100 mg
• Synonym: glyburide, glibenclamide, glybenclamide, micronase, diabeta, glynase, daonil, euglucon, maninil, semi-daonil
• InChI Key: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
• IUPAC Name: 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
• Molecular Weight (g/mol): 494.003
• PubChem CID: 3488
• ChEBI: CHEBI:5441
• Formula Weight: 494
• Percent Purity: >99%
• Chemical Name or Material: Glibenclamide