Glycyl-H 1152 dihydrochloride, Tocris Bioscience™

Description

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Specifications

• CAS: 913844-45-8
• Molecular Formula: C18H26Cl2N4O3S
• Quantity: 1 mg
• Synonym: rho kinase inhibitor iv, h-1152 glycyl dihydrochloride
• InChI Key: ILDBNQGLZFSHQZ-FMOMHUKBSA-N
• SMILES: CC1CN(CCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C)C(=O)CN.Cl.Cl
• IUPAC Name: 2-amino-1-[(3R)-3-methyl-4-(4-methylisoquinolin-5-yl)sulfonyl-1,4-diazepan-1-yl]ethanone;dihydrochloride
• Molecular Weight (g/mol): 449.391
• PubChem CID: 71433876
• Formula Weight: 449.4
• Percent Purity: >99%
• Chemical Name or Material: Glycyl-H 1152 dihydrochloride