GMPS Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5109775

Product Code. 17177703

Description

Immunogen sequence: DTELIRKLRE EGKVIEPLKD FHKDEVRILG RELGLPEELV SRHPFPGPGL AIRVICAEEP YICKDFPETN NILKIVADFS ASVKKPHTLL QRVKACTTEE DQEKLMQITS LHSLNAFLLP IKTVGVQGDC RSYSYVCGIS SKDEPDWESL IFLARLIPRM CHNVNRVVYI FGPPVKEPPT DVTPTFLTTG VLSTLRQADF EAHNILRESG YAGKISQMPV ILTPLHFDRD PLQKQPSCQR SVVIRTFITS DFMTGIPATP GNEIPVEVVL KMVTEIKKIP GISRIMYDLT SKPPGTTEWE

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Specifications

• Antigen: GMPS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GMPS
• Gene Alias: AA591640; AI047208; Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; GMPS; guanine monophosphate synthase; guanine monophosphate synthetase; guanine monphosphate synthase; guanine monphosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion protein; testicular tissue protein Li 82
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 229363, 295088, 8833
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 2.69 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P49915, Q3THK7, Q4V7C6
• Gene Symbols: GMPS
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 394-693 of human GMPS (NP_003866.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG