Tocris Bioscience™ Go 6976

Potent protein kinase C inhibitor; selective for α and β isozymes

Brand:  Tocris Bioscience™ 2253/500U

Product Code. 18094722

Description

Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.

Specifications

• Chemical Name or Material: 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
• Quantity: 500 μg
• Molecular Formula: C₂₄H₁₈N₄O

• CAS: 136194-77-9
• Target: Protein Kinase C Inhibitors
• Purity: 95%