GS 39783, Tocris Bioscience™

Description

Positive allosteric modulator of GABAB receptors

Positive allosteric modulator of GABAB receptor function. Potentiates the effects of GABA on [35S]GTPγS binding at recombinant and native GABAB receptors (EC50 values are 2.1 and 3.1μM respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

Specifications

Chemical Identifiers

• CAS: 39069-52-8
• Molecular Formula: C15H23N5O2S
• Molecular Weight (g/mol): 337.442
• InChI Key: GSGVDKOCBKBMGG-UHFFFAOYSA-N
• Synonym: n4,n6-dicyclopentyl-2-methylthio-5-nitropyrimidine-4,6-diamine, 4,6-pyrimidinediamine, n,n'-dicyclopentyl-2-methylthio-5-nitro, n,n'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine, n4,n6-dicyclopentyl-2-methylsulfanyl-5-nitropyrimidine-4,6-diamine, pseudoephedrine, +, tocris-2001, gs hplc, n,n'-dicyclopentyl-2-methylthio-5-nitro-4,6-pyrimidinediamine, n4,n6-dicyclopentyl-2-methylthio-5-nitro-4,6-pyrimidinediamine
• PubChem CID: 6604928
• IUPAC Name: 4-N,6-N-dicyclopentyl-2-methylsulfanyl-5-nitropyrimidine-4,6-diamine
• SMILES: CSC1=NC(=C(C(=N1)NC2CCCC2)[N+](=O)[O-])NC3CCCC3

• Quantity: 10 mg
• Formula Weight: 337.44
• Percent Purity: >98%
• Chemical Name or Material: GS 39783