Harmine, 98+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11359615	Thermo Scientific Alfa Aesar L19068.MD	250 mg
11349615	Thermo Scientific Alfa Aesar L19068.03	1 g

Description

Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

Solubility
Soluble in DMSO (100 mM), DMF (∼1.5 mg/ml), ethanol (∼1.5 mg/ml), and PBS (pH 7.2, ∼0.25 mg/ml). Insoluble in water.

Notes
Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Chemical Identifiers

• CAS: 442-51-3
• Molecular Weight (g/mol): 212.25
• InChI Key: BXNJHAXVSOCGBA-UHFFFAOYSA-N
• PubChem CID: 5280953
• IUPAC Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

• Molecular Formula: C13H12N2O
• MDL Number: MFCD00004958
• Synonym: harmine, 7-methoxy-1-methyl-9h-pyrido 3,4-b indole, banisterine, leucoharmine, telepathine, yageine, yajeine, 7-methoxy-1-methyl-9h-beta-carboline, 9h-pyrido 3,4-b indole, 7-methoxy-1-methyl, banisterin
• ChEBI: CHEBI:28121
• SMILES: COC1=CC2=C(C=C1)C1=C(N2)C(C)=NC=C1

Specifications

• CAS: 442-51-3
• Odor: Odorless
• MDL Number: MFCD00004958
• Merck Index: 14,4616
• Solubility Information: Soluble in DMSO (100 mM),DMF (∽1.5mg/ml),ethanol (∽1.5mg/ml),and PBS (pH 7.2,∽0.25mg/ml). Insoluble in water.
• SMILES: COC1=CC2=C(C=C1)C1=C(N2)C(C)=NC=C1
• Molecular Weight (g/mol): 212.25
• ChEBI: CHEBI:28121
• Percent Purity: ≥98%

• Melting Point: 262°C to 266°C
• Molecular Formula: C13H12N2O
• Beilstein: 178813
• Synonym: harmine, 7-methoxy-1-methyl-9h-pyrido 3,4-b indole, banisterine, leucoharmine, telepathine, yageine, yajeine, 7-methoxy-1-methyl-9h-beta-carboline, 9h-pyrido 3,4-b indole, 7-methoxy-1-methyl, banisterin
• InChI Key: BXNJHAXVSOCGBA-UHFFFAOYSA-N
• IUPAC Name: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
• PubChem CID: 5280953
• Formula Weight: 212.25
• Chemical Name or Material: Harmine

Safety and Handling

GHS H Statement
H302-H332-H319
Harmful if swallowed.
Harmful if inhaled.
Causes serious eye irritation.

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P363-P501c

H302+H312+H332-H319

missing translation for 'dotInformation' : Hazard Class: 6.1; Packaging Group: III

missing translation for 'einecsNumber' : 207-131-4

missing translation for 'rtecsNumber' : UV0175000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only