HDAC9 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA511245

Product Code. 10008739

Description

This antibody is predicted to react with chicken and mouse based on sequence homology.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.

Specifications

• Antigen: HDAC9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hdac9
• Gene Alias: AV022454; D030072B18Rik; DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; Hdac7b; HDAC9; hdac-9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4/5-related protein; histone deacetylase 7B; Histone deacetylase 9; histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; Mitr; mKIAA0744; RGD1310748; RGD1563092; TWIST
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 79221, 9734
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q99N13, Q9UKV0
• Gene Symbols: Hdac9
• Immunogen: KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG