Herbimycin A, Tocris Bioscience™

Description

Src family kinase inhibitor. Also Hsp90 inhibitor

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Specifications

• Type: Herbimycin A
• CAS: 70563-58-5
• Molecular Formula: C30H42N2O9
• Synonym: (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
• InChI Key: MCAHMSDENAOJFZ-HYKLGOSOSA-N
• SMILES: CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
• IUPAC Name: [(2S,3R,6S,7R,8E,10R,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• Molecular Weight (g/mol): 574.671
• PubChem CID: 133268477
• Formula Weight: 574.67
• Percent Purity: 95%
• Quantity: 100 μg
• Chemical Name or Material: Herbimycin A