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Herbimycin A, Tocris Bioscience™

Product Code. 30001388
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Quantity:
100 μg
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This item is not returnable. View return policy

Description

Src family kinase inhibitor. Also Hsp90 inhibitor

Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Exhibits antiangiogenic activity in endothelial cells in vitro. Also inhibits Hsp90 and impairs recovery from heat shock.

Specifications

Type Herbimycin A
CAS 70563-58-5
Quantity 100 μg
Molecular Formula C30H42N2O9
Synonym (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin
InChI Key MCAHMSDENAOJFZ-HYKLGOSOSA-N
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
IUPAC Name [(2S,3R,6S,7R,8E,10R,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Molecular Weight (g/mol) 574.671
PubChem CID 133268477
Formula Weight 574.67
Percent Purity 95%
Chemical Name or Material Herbimycin A
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