Hesperadin hydrochloride, Tocris Bioscience™

Description

Potent Aurora kinase B inhibitor

ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol - and taxol -treated HeLa cells.

Specifications

Chemical Identifiers

• CAS: 422513-13-1
• Molecular Formula: C29H32N4O3S
• Molecular Weight (g/mol): 516.66
• InChI Key: GLDSKRNGVVYJAB-DQSJHHFOSA-N
• Synonym: hesperadin, hesperadine, unii-ptr491os14, z-n-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylene indolin-5-yl ethanesulfonamide, n-3z-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylidene-2,3-dihydro-1h-indol-5-yl ethanesulfonamide, n-3z-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylidene-1h-indol-5-yl ethanesulfonamide, n-2,3-dihydro-2-oxo-3-3z-phenyl 4-1-piperidinylmethyl phenyl amino methylene-1h-indol-5-yl ethanesulfonamide, hesperadin/, d05wsm, ethanesulfonamide, n-2,3-dihydro-2-oxo-3-3z-phenyl 4-1-piperidinylmethyl phenyl amino methylene-1h-indol-5-yl
• PubChem CID: 10142586
• ChEBI: CHEBI:70726
• IUPAC Name: N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide
• SMILES: CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5

• Quantity: 10 mg
• Formula Weight: 553.12
• Percent Purity: >99%
• Chemical Name or Material: Hesperadin hydrochloride