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Hesperadin hydrochloride, Tocris Bioscience™

Product Code. 18054692
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent Aurora kinase B inhibitor

ATP-competitive inhibitor of Aurora B kinase (IC50 = 250 nM). Prevents chromosome alignment and segregation; also induces polyploidy and prevents histone H3-Ser10 phosphorylation. Overrides the spindle assembly checkpoint and induces mitotic exit in monastrol - and taxol -treated HeLa cells.

Chemical Identifiers

CAS 422513-13-1
Molecular Formula C29H32N4O3S
Molecular Weight (g/mol) 516.66
InChI Key GLDSKRNGVVYJAB-DQSJHHFOSA-N
Synonym hesperadin, hesperadine, unii-ptr491os14, z-n-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylene indolin-5-yl ethanesulfonamide, n-3z-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylidene-2,3-dihydro-1h-indol-5-yl ethanesulfonamide, n-3z-2-oxo-3-phenyl 4-piperidin-1-ylmethyl phenyl amino methylidene-1h-indol-5-yl ethanesulfonamide, n-2,3-dihydro-2-oxo-3-3z-phenyl 4-1-piperidinylmethyl phenyl amino methylene-1h-indol-5-yl ethanesulfonamide, hesperadin/, d05wsm, ethanesulfonamide, n-2,3-dihydro-2-oxo-3-3z-phenyl 4-1-piperidinylmethyl phenyl amino methylene-1h-indol-5-yl
PubChem CID 10142586
ChEBI CHEBI:70726
IUPAC Name N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indol-5-yl]ethanesulfonamide
SMILES CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=O)C2=C(C3=CC=CC=C3)NC4=CC=C(C=C4)CN5CCCCC5

Specifications

Quantity 10 mg
Formula Weight 553.12
Percent Purity >99%
Chemical Name or Material Hesperadin hydrochloride
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