HPV Type 16 E7 Monoclonal Antibody (TVG701Y), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA514132

Product Code. 11344993

Description

MA5-14132 targets Human Papilloma Virus Type 16-E7 (HPV 16-E7) in FACS and IF applications and shows reactivity with Virus samples. The MA5-14132 immunogen is recombinant HPV-16 E7 protein.

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.

Specifications

• Antigen: HPV Type 16 E7
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunocytochemistry
• Clone: TVG701Y
• Conjugate: Unconjugated
• Gene Alias: HPV 16-E7; HPV16E7; human papillomavirus
• Immunogen: Recombinant HPV-16 E7 protein
• Quantity: 500 μL
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Form: Liquid