Abnova™ Human ANPEP (967 amino acids) native Protein from human serum

Used for Func, SDS-PAGE

Brand:  Abnova™ P4918.10ug

Product Code. 16058076

Description

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq]

Specifications

• For Use With (Application): Functional Study, SDS-PAGE
• Gene ID (Entrez): 290
• Name: ANPEP (Human) Native Protein
• Purification Method: Saltprecipitation/Ion Exchange Chromatography/Gelfiltration
• Quantity: 10 ug
• Regulatory Status: RUO
• Common Name: ANPEP
• Biological Activity: > 500mU/mg (L-Leu-pNA at 37°C, pH 7.2).
• Protein Tag: None
• Form: Liquid

• Formulation: In 20mM Tris-HCl, 500mM NaCl, 1mM CaCl
• Molecular Weight (g/mol): 110-130kDa
• Preparation Method: Native protein purified from human serum
• Quality Control Testing: 15% SDS-PAGE Stained with Coomassie Blue
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Gene Alias: APN/CD13/LAP1/PEPN/gp150/p150
• Gene Symbol: ANPEP
• Species: Human
• Expression System: Native protein purified from human serum
• Purity or Quality Grade: >90% by SDS-PAGE