missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Gibco™ Human IL-1 alpha Recombinant Protein, PeproTech®
E. coli Recombinant Protein
£64.75 - £3110.00
Specifications
Accession Number | P01583 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 3552 |
Molecular Weight (g/mol) | 18 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17801843
|
Gibco™
200-01A-100UG |
100 μg |
£622.00
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17830783
|
Gibco™
200-01A-10UG |
10 μg |
£157.00
10µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17840323
|
Gibco™
200-01A-1MG |
1 mg |
£3110.00
1mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17821833
|
Gibco™
200-01A-250UG |
250 μg |
£1090.00
250µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17851063
|
Gibco™
200-01A-2UG |
2 μg |
£64.75
2µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17810863
|
Gibco™
200-01A-500UG |
500 μg |
£1868.00
500µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17870503
|
Gibco™
200-01A-50UG |
50 μg |
£375.00
50µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.Specifications
P01583 | |
protein with no preservative | |
18 | |
E. coli | |
RUO | |
CTLA8; hematopoietin-1; IL 1 A; IL 1 A; IL1; IL-1 alpha; IL17; IL1A; Il-1 A; IL-1 alpha; IL1-ALPHA; IL1F1; IL1a; ILN; Interleukin; interleukin 1 alpha; interleukin 1, alpha; interleukin 17; interleukin 1 A; interleukin 1-alpha; interleukin 1-alpha (AA 1 - 152); Interleukin1 alpha; interleukin-1 alpha; interleukin-1 alpha precursor; Interleukin-17 A; preinterleukin 1 alpha; pre-interleukin-1 alpha; pro-interleukin-1-alpha; RP23-160G19.8 | |
Human | |
Recombinant | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
3552 | |
Human IL-1 alpha | |
-20°C | |
<1 EU/μg | |
Il1a | |
Unconjugated | |
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |