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Gibco™ Human IL-1 alpha Recombinant Protein, PeproTech®

E. coli Recombinant Protein

£64.75 - £3110.00

Specifications

Accession Number P01583
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 3552
Molecular Weight (g/mol) 18
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17801843
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Gibco™
200-01A-100UG
100 μg
£622.00
100µg
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17830783
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Gibco™
200-01A-10UG
10 μg
£157.00
10µg
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17840323
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Gibco™
200-01A-1MG
1 mg
£3110.00
1mg
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17821833
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Gibco™
200-01A-250UG
250 μg
£1090.00
250µg
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17851063
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Gibco™
200-01A-2UG
2 μg
£64.75
2µg
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17810863
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Gibco™
200-01A-500UG
500 μg
£1868.00
500µg
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17870503
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Gibco™
200-01A-50UG
50 μg
£375.00
50µg
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Description

Description

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

P01583
protein with no preservative
18
E. coli
RUO
CTLA8; hematopoietin-1; IL 1 A; IL 1 A; IL1; IL-1 alpha; IL17; IL1A; Il-1 A; IL-1 alpha; IL1-ALPHA; IL1F1; IL1a; ILN; Interleukin; interleukin 1 alpha; interleukin 1, alpha; interleukin 17; interleukin 1 A; interleukin 1-alpha; interleukin 1-alpha (AA 1 - 152); Interleukin1 alpha; interleukin-1 alpha; interleukin-1 alpha precursor; Interleukin-17 A; preinterleukin 1 alpha; pre-interleukin-1 alpha; pro-interleukin-1-alpha; RP23-160G19.8
Human
Recombinant
Lyophilized
ELISA, Functional Assay, Western Blot
3552
Human IL-1 alpha
-20°C
<1 EU/μg
Il1a
Unconjugated
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
≥ 98% by SDS-PAGE gel and HPLC analyses.
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