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Gibco™ Human IL-1 beta Recombinant Protein, PeproTech®
E. coli Recombinant Protein
£64.75 - £3110.00
Specifications
Accession Number | P01584 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Gene ID (Entrez) | 3553 |
Molecular Weight (g/mol) | 17.3 |
Name | Human IL-1 beta |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17870783
|
Gibco™
200-01B-100UG |
100 μg |
£622.00
100µg |
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17810723
|
Gibco™
200-01B-10UG |
10 μg |
£157.00
10µg |
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30089405
|
Gibco™
200-01B-01M |
2 x 500 μg |
£3110.00
Pack of 2 |
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17880503
|
Gibco™
200-01B-1MG |
2 x 500 μg | N/A | ||||||
17839952
|
Gibco™
200-01B-250UG |
250 μg |
£1090.00
250µg |
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17820033
|
Gibco™
200-01B-2UG |
2 μg |
£64.75
2µg |
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17800903
|
Gibco™
200-01B-500UG |
500 μg |
£1868.00
500µg |
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17841063
|
Gibco™
200-01B-50UG |
50 μg |
£375.00
50µg |
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Description
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.Specifications
P01584 | |
3553 | |
Human IL-1 beta | |
-20°C | |
<1 EU/μg | |
IL1B | |
Unconjugated | |
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
ELISA, Functional Assay, Western Blot | |
17.3 | |
E. coli | |
RUO | |
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1 b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1 B; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 b; interleukin-1 beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta | |
Human | |
Recombinant | |
Lyophilized |