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Gibco™ Human IL-1 beta Recombinant Protein, PeproTech®

E. coli Recombinant Protein

£64.75 - £3110.00

Specifications

Accession Number P01584
For Use With (Application) ELISA, Functional Assay, Western Blot
Gene ID (Entrez) 3553
Molecular Weight (g/mol) 17.3
Name Human IL-1 beta
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Products 8
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17870783
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Gibco™
200-01B-100UG
100 μg
£622.00
100µg
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17810723
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Gibco™
200-01B-10UG
10 μg
£157.00
10µg
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30089405
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Gibco™
200-01B-01M
2 x 500 μg
£3110.00
Pack of 2
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17880503
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Gibco™
200-01B-1MG
2 x 500 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
17839952
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Gibco™
200-01B-250UG
250 μg
£1090.00
250µg
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17820033
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Gibco™
200-01B-2UG
2 μg
£64.75
2µg
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17800903
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Gibco™
200-01B-500UG
500 μg
£1868.00
500µg
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17841063
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Gibco™
200-01B-50UG
50 μg
£375.00
50µg
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Description

Description

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

P01584
3553
Human IL-1 beta
-20°C
<1 EU/μg
IL1B
Unconjugated
APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
≥ 98% by SDS-PAGE gel and HPLC analyses.
ELISA, Functional Assay, Western Blot
17.3
E. coli
RUO
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1 b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1 B; IL1B1; IL1beta; IL-1 beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 b; interleukin-1 beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
Human
Recombinant
Lyophilized
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