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Gibco™ Human IL-17F Recombinant Protein, PeproTech®

E. coli Recombinant Protein

£64.75 - £2400.00

Specifications

Accession Number Q96PD4
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 112744
Molecular Weight (g/mol) 30.1
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17860733
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Gibco™
200-25-100UG
100 μg
£480.00
100µg
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17850913
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Gibco™
200-25-1MG
1 mg
£2400.00
1mg
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17830233
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Gibco™
200-25-250UG
250 μg
£838.00
250µg
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17891873
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Gibco™
200-25-25UG
25 μg
£157.00
25µg
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17801113
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Gibco™
200-25-500UG
500 μg
£1436.00
500µg
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17860433
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Gibco™
200-25-50UG
50 μg
£291.00
50µg
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17851703
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Gibco™
200-25-5UG
5 μg
£64.75
5µg
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Description

Description

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Specifications

Specifications

Q96PD4
protein with no preservative
30.1
E. coli
RUO
C87042; CANDF6; cytokine ML-1; IL17F; IL-17 F; IL-24; ILN; Interleukin; interleukin 17 F; Interleukin17F; interleukin-17 F; interleukin-24; ML1; ML-1; mutant IL-17 F
Human
Recombinant
Lyophilized
ELISA, Functional Assay, Western Blot
112744
Human IL-17 F
-20°C
<1 EU/μg
IL17F
Unconjugated
MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
≥ 98% by SDS-PAGE gel and HPLC analyses.
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