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Gibco™ Human IL-21 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

£64.75 - £4150.00

Specifications

Accession Number Q9HBE4
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 59067
Molecular Weight (g/mol) 15.4
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17860243
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Gibco™
200-21-100UG
100 μg
£832.00
100µg
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17820633
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Gibco™
200-21-10UG
10 μg
£157.00
10µg
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17831003
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Gibco™
200-21-1MG
1 mg
£4150.00
1mg
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17811883
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Gibco™
200-21-250UG
250 μg
£1456.00
250µg
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17891413
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Gibco™
200-21-2UG
2 μg
£64.75
2µg
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17831103
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Gibco™
200-21-500UG
500 μg
£2495.00
500µg
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17890223
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Gibco™
200-21-50UG
50 μg
£502.00
50µg
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Description

Description

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
Specifications

Specifications

Q9HBE4
protein with no preservative
15.4
E. coli
RUO
CVID11; C x 2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Human
Recombinant
Lyophilized
ELISA, Functional Assay, Western Blot
59067
Human IL-21
-20°C
<1 EU/μg
IL21
Unconjugated
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
≥ 98% by SDS-PAGE gel and HPLC analyses.
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