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Gibco™ Human IL-21 Recombinant Protein, PeproTech®
E. coli Recombinant Protein
£64.75 - £4150.00
Specifications
Accession Number | Q9HBE4 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 59067 |
Molecular Weight (g/mol) | 15.4 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17860243
|
Gibco™
200-21-100UG |
100 μg |
£832.00
100µg |
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17820633
|
Gibco™
200-21-10UG |
10 μg |
£157.00
10µg |
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17831003
|
Gibco™
200-21-1MG |
1 mg |
£4150.00
1mg |
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17811883
|
Gibco™
200-21-250UG |
250 μg |
£1456.00
250µg |
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17891413
|
Gibco™
200-21-2UG |
2 μg |
£64.75
2µg |
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17831103
|
Gibco™
200-21-500UG |
500 μg |
£2495.00
500µg |
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17890223
|
Gibco™
200-21-50UG |
50 μg |
£502.00
50µg |
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Description
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.Specifications
Q9HBE4 | |
protein with no preservative | |
15.4 | |
E. coli | |
RUO | |
CVID11; C x 2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11 | |
Human | |
Recombinant | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
59067 | |
Human IL-21 | |
-20°C | |
<1 EU/μg | |
IL21 | |
Unconjugated | |
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |