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Invitrogen™ Human MRP2 Vesicles

Human MRP2 Vesicles are insect derived purified plasma membranes that carry MRP2 transport protein (multidrug resistance-associated protein, ABCC2). The ATP-binding cassette transporter carries organic anions and can be used to evaluate test compounds and drug interactions with in in vitro assays.

Brand:  Invitrogen™ GM0001

Product Code. 10252500

  • £856.00 / Each

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For Research Use Only. All usage must comply with product instructions.
 
This item is not returnable. View return policy

Description

Description

Use Human MRP2 Vesicles to:

  • Investigate the transporter interactions of your drug candidates
  • Assess potential for transporter-mediated drug-drug interactions
  • Obtain high quality results with a large signal to noise ratios

Concept Behind ABC Transporter Vesicles
ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate 's substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.

Clear and Reliable Results
Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these inside-out vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.

Transporter Vesicle Details
Human MRP2 Vesicles are part of a larger group of transporter vesicles known as ABC transporter vesicles. They are prepared from purified plasma membranes isolated from an insect cell system (Sf9 cells transfected with baculovirus) expressing MRP2. MRP2 is expressed in various organs, and is thought to play a role in excretion of various compounds from the kidney and liver, based on its localization on the canalicular plasma membrane of hepatocytes and brush border membrane of tubular epithelial cells.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Frozen
Research Grade
Store at -80°C.
Dry Ice
0.5 mL
Human
Vial
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For Research Use Only. Not for use in diagnostic procedures.