ACROBiosystems Human OX40 Ligand / TNFSF4 Protein, His Tag (active trimer)

MALS verified

Product Code	Brand	Quantity
15689753	ACROBiosystems OXL-H52Q8-50UG	50 μg
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15887417	ACROBiosystems OXL-H52Q8-1MG	1 mg

Description

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 16.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

• Accession Number: NP_003317
• Source: Human O x 40 Ligand, His Tag (active trimer) (OXL-H52Q8) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # NP_003317).
• Storage Requirements: -20°C
• Common Name: OX40 Ligand
• Species: Human
• Buffer: PBS, pH7.4
• Expression System: HEK293
• Protein Subtype: Immune Checkpoint Proteins

• Molecular Weight (g/mol): 16.9 kDa
• Immunogen: Gln 51 - Leu 183
• Gene Alias: OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
• Conjugate: Unconjugated
• Protein Tag: His Tag
• Endotoxin Level: Less than 1.0 EU / μg by the LAL method.
• Form: Powder
• Purity or Quality Grade: >90% as determined by SDS-PAGE