Gibco™ Human PDGF-BB Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Product Code	Brand	Quantity
17880383	Gibco™ 100-14B-100UG	100 μg
17850403	Gibco™ 100-14B-10UG	10 μg
17839912	Gibco™ 100-14B-1MG	1 mg
17870883	Gibco™ 100-14B-250UG	250 μg
17831333	Gibco™ 100-14B-2UG	2 μg
17880083	Gibco™ 100-14B-500UG	500 μg
17821023	Gibco™ 100-14B-50UG	50 μg

Description

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Specifications

• Accession Number: P01127
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 24.3
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: becaplermin; c-sis; FLJ12858; H-PDGF-BB; IBGC5; PDGF; pdgf protein; PDGF subunit B; PDGF, B chain; PDGF2; PDGF-2; PDGFB; PDGF-B; platelet derived growth factor subunit B; platelet derived growth factor, B polypeptide; platelet-derived growth factor 2; platelet-derived growth factor B; platelet-derived growth factor B chain; platelet-derived growth factor beta; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); proto-oncogene c-Sis; Sis; SSV
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 5155
• Name: Human PDGF-BB
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: PDGFB
• Conjugate: Unconjugated
• Sequence: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.