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STEMCELL Technologies Human Recombinant IL-2, ACF

Product Code. p-7217568
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10µg
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Product Code. 17119681

Brand: STEMCELL Technologies 78145

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Description

Interleukin 2, animal component-free

  • Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
  • It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
  • Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.) The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
  • IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ T regulatory cells and affects development of follicular helper T cells
  • IL-2 also controls inflammation by inhibiting Th17 differentiation
  • This product is animal component-free

Specifications

Name Aldesleukin, Interleukin-2, T cell growth factor, TCGF
Quantity 10 μg
Cell Type Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+
Purity or Quality Grade ≥95%
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