Gibco™ Human VEGF-B Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Product Code	Brand	Quantity
17860013	Gibco™ 100-20B-100UG	100 μg
17810193	Gibco™ 100-20B-1MG	1 mg
17831033	Gibco™ 100-20B-20UG	20 μg
17850653	Gibco™ 100-20B-250UG	250 μg
17821333	Gibco™ 100-20B-500UG	500 μg
17881503	Gibco™ 100-20B-5UG	5 μg

Description

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13.

Specifications

• Accession Number: P49765
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 38
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: flt-1/VEGFR1 ligand; vascular endothelial growth factor B; vascular endothelial growth factor B167 precursor; vascular endothelial growth factor B186 precursor; vascular endothelial growth factor-B; Vegfb; VEGF-B; VEGFL; VEGF-related factor; Vrf
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 7423
• Name: Human VEGF-B
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: VEGFB
• Conjugate: Unconjugated
• Sequence: PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.