Proteintech HumanKine™ recombinant human IGF-I protein

HumanKine™ recombinant protein

Product Code	Brand	Quantity
17600097	Proteintech HZ-1322-10UG	10 μg
17680087	Proteintech HZ-1322-1000UG	1000 μg
17690087	Proteintech HZ-1322-100UG	100 μg

Description

The Insulin like growth factor-1, also known as Somatomedin-C is a growth factor which is structurally related to insulin and is an important regulator of growth and differentiation in various tissues and cell systems. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C-terminal propeptide. The two precursor isoforms are differentially expressed by various tissues. The proteolytic cleavage of the N- and C-terminal regions results in the mature IGF-1 protein which is identical between isoforms. IGF-1 binds to IGF-1 receptor and induces receptor autophosphorylation. This further phosphorylates Insulin receptor substrate -1 (IRS-1) and activates various downstream signaling pathways including the PI3-AKT, MAPK etc. (PMID: 17354613, 17113337, 29535161)

Specifications

• Accession Number: P05019
• Gene ID (Entrez): 3479
• Source: HEK293
• Endotoxin Concentration: <1 EU/μg
• Recombinant: Recombinant
• Activity: 2-14 ng/mL EC50
• Purity or Quality Grade: >95%

• Formulation: 1 x PBS pH 7.4
• Molecular Weight (g/mol): 10 kDa
• Storage Requirements: Lyophilized product should be stored at -20°C to -80°C until expiry date and (at Room Temperature for 2 weeks.)
• Specific Reactivity: Human
• Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1 xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
• Form: Lyophilized