Hydrogen fluoride pyridine complex, ca 70% HF, Thermo Scientific Chemicals

Description

Hydrogen fluoride pyridine complex is used to prepare beta-fluoroamines via reaction with amino alcohols. As a fluorinating agent, is involved in the fluorination of 2,2-diary-1,3-dithiolanes. It is associated with nitrosonium tetrafluorborate to prepare gem-difluorides by reacting with ketoximes. It is also used to convert secondary and tertiary alcohols into their respective alkyl fluorides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Hydrogen fluoride pyridine complex is used to prepare beta-fluoroamines via reaction with amino alcohols. As a fluorinating agent, is involved in the fluorination of 2,2-diary-1,3-dithiolanes. It is associated with nitrosonium tetrafluorborate to prepare gem-difluorides by reacting with ketoximes. It is also used to convert secondary and tertiary alcohols into their respective alkyl fluorides.

Notes
Moisture sensitive. Store in cool place. Incompatible with strong bases, alkali metals, strong oxidizing agents, metals and strong acids. It reacts violently with water.

Specifications

Chemical Identifiers

• CAS: 62778-11-4
• Molecular Formula: C5H6FN
• Molecular Weight (g/mol): 99.108
• MDL Number: MFCD00012436
• InChI Key: GRJJQCWNZGRKAU-UHFFFAOYSA-N
• Synonym: pyridine hydrofluoride, hydrogen fluoride-pyridine, olah's reagent, pyridinium fluoride, hydrogen fluoride pyridine complex, hydrogen fluoride pyridine, hf-pyridine, pyridine, hydrofluoride 1:1, pyridinium poly hydrogen fluoride, hydrogen fluoride/pyridine
• PubChem CID: 64774
• IUPAC Name: pyridine;hydrofluoride
• SMILES: C1=CC=NC=C1.F

• Density: 1.1
• Boiling Point: 50°C (1 mmHg)
• Quantity: 25 g
• UN Number: UN1790
• Beilstein: 4750151
• Sensitivity: Moisture sensitive
• Merck Index: 14,6821
• Assay: ≈70% HF
• Chemical Name or Material: Hydrogen fluoride pyridine complex

Safety and Handling

Product Identifier

• Hydrogen fluoride pyridine complex

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Acute toxicity Category 2
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 A

Hazard Statement

• H300-Fatal if swallowed.
• H310-Fatal in contact with skin.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H330-Fatal if inhaled.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.
• P330-Rinse mouth.

Supplemental information

• MIXTURE LIST-Contains : Hydrogen fluoride pyridine

RUO – Research Use Only