Hydroxyurea, 98%, Thermo Scientific Chemicals

Description

Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.

Notes
Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 127-07-1
• Molecular Formula: CH4N2O2
• Molecular Weight (g/mol): 76.055
• MDL Number: MFCD00007943
• InChI Key: VSNHCAURESNICA-UHFFFAOYSA-N
• Synonym: hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
• PubChem CID: 3657
• ChEBI: CHEBI:44423
• IUPAC Name: hydroxyurea
• SMILES: C(=O)(N)NO

• Melting Point: ∽140°C (decomposition)
• Assay Percent Range: 98%
• Quantity: 1 g
• Beilstein: 1741548
• Solubility Information: Soluble in water,hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.
• Formula Weight: 76.06
• Chemical Name or Material: Hydroxyurea

Safety and Handling

Product Identifier

• Hydroxyurea

Signal Word

• Danger

Hazard Category

• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 1A

Hazard Statement

• H340-May cause genetic defects.
• H360D-May damage the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Hydroxyurea

RUO – Research Use Only