IEM 1460, Tocris Bioscience™

Description

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Specifications

Chemical Identifiers

• CAS: 121034-89-7
• Molecular Formula: C19H38Br2N2
• Molecular Weight (g/mol): 454.335
• InChI Key: CQTDZUSQSTUZDA-UHFFFAOYSA-M
• Synonym: tocris-1636, 5-1-adamantylmethylamino pentyl-trimethylazanium bromide hydrobromide, 5-adamantan-1-ylmethyl amino pentyl trimethylazanium hydrobromide bromide, n,n,h,-trimethyl-5-tricyclo 3.3.1.13,7 dec-1-ylmethyl amino-1-pentanaminiumbromide hydrobromide
• PubChem CID: 6604954
• IUPAC Name: 5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide
• SMILES: C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

• Quantity: 10 mg
• Formula Weight: 454.33
• Percent Purity: >98%
• Chemical Name or Material: IEM 1460