IEM 1925 dihydrobromide, Tocris Bioscience™

Description

Voltage- and use-dependent open-channel antagonist of AMPA receptors

IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Specifications

Chemical Identifiers

• CAS: 258282-23-4
• Molecular Formula: C17H30Br2N2
• Molecular Weight (g/mol): 422.249
• InChI Key: ZCYUSVRXEKAQSL-UHFFFAOYSA-N
• Synonym: iem 1925 dihydrobromide, n-1-phenylcyclohexyl-1,5-pentanediamine dihydrobromide
• PubChem CID: 44561101
• IUPAC Name: N'-(1-phenylcyclohexyl)pentane-1,5-diamine;dihydrobromide
• SMILES: C1CCC(CC1)(C2=CC=CC=C2)NCCCCCN.Br.Br

• Quantity: 10 mg
• Formula Weight: 422.24
• Percent Purity: 95%
• Chemical Name or Material: IEM 1925 dihydrobromide