Learn More
IL-12/IL-23 p40 Monoclonal Antibody (C8.6), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£247.00
Specifications
Antigen | IL-12/IL-23 p40 |
---|---|
Clone | C8.6 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Description
Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits. Applications Tested: This C8.6 antibody has been pre-titrated and tested by intracellular staining of IFN gamma LPS actiavted human normal human peripheral blood cells. This can be used at 5 μL (0.03 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.Specifications
IL-12/IL-23 p40 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
C8.6 | |
Flow Cytometry | |
Alexa Fluor 488 | |
Mouse | |
Human | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
IL12B |
For Research Use Only.