iMDK, Tocris Bioscience™

Description

Suppressor of MDK expression; inhibits PI 3-K signaling

Suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.

Specifications

Chemical Identifiers

• CAS: 881970-80-5
• Molecular Formula: C21H13FN2O2S
• Molecular Weight (g/mol): 376.405
• InChI Key: IWFKQTWYILKFGE-UHFFFAOYSA-N
• Synonym: imdk, 3-2-4-fluorobenzyl imidazo 2,1-b 1,3 thiazol-6-yl-2h-chromen-2-one, 3-2-4-fluorophenyl methyl imidazo 2,1-b thiazol-6-yl-2h-1-benzopyran-2-one, 3-2-4-fluorophenyl methyl imidazo 2,1-b 1,3 thiazol-6-yl chromen-2-one, 3-2-4-fluorophenyl methyl imidazo 2,1-b 1,3-thiazolin-6-yl chromen-2-one
• PubChem CID: 15991416
• IUPAC Name: 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl]chromen-2-one
• SMILES: C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN4C=C(SC4=N3)CC5=CC=C(C=C5)F

• Quantity: 10 mg
• Formula Weight: 376.4
• Chemical Name or Material: iMDK