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Importin 11 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA564308
This item is not returnable.
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Description
Immunogen sequence: QLLGNMIEMW VDRMDNITQP ERRKLSALAL LSLLPSDNSV IQDKFCGIIN ISVEGLHDVM TEDPETGTYK DCMLMSHLEE PKVTEDEEPP TEQD Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 77%.
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
Specifications
| Importin 11 | |
| Polyclonal | |
| Unconjugated | |
| IPO11 | |
| 1700081H05Rik; 2510001A17Rik; AI314624; AW555235; E330021B14Rik; Imp11; importin 11; importin-11; IPO11; Ran binding protein 11; ran-binding protein 11; Ranbp11 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 51194 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| 0.5 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9UI26 | |
| IPO11 | |
| Recombinant protein corresponding to Human Importin 11 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Research Use Only