Indomethacin, 98%, Thermo Scientific Chemicals

Description

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Notes
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 53-86-1
• Molecular Formula: C19H16ClNO4
• Molecular Weight (g/mol): 357.79
• MDL Number: MFCD00057095
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• PubChem CID: 3715
• ChEBI: CHEBI:49662
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

• Melting Point: 158°C to 161°C
• Assay Percent Range: 0.98
• Quantity: 5 g
• UN Number: UN2811
• Beilstein: 497341
• Sensitivity: Light sensitive
• Merck Index: 14,4968
• Solubility Information: Soluble in acetone (40mg/mL- clear,yellow solution),ethanol (20mg/mL),ether,castor oil; Soluble in chloroform (50mg/mL- clear,yellow,extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
• Formula Weight: 357.8
• Percent Purity: 98%
• Chemical Name or Material: Indomethacin

Safety and Handling

Product Identifier

• Indomethacin

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Reproductive toxicity Category 1B
• Skin sensitiser Category 1

Hazard Statement

• H300-Fatal if swallowed.
• H317-May cause an allergic skin reaction.
• H360FD-May damage fertility. May damage the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P330-Rinse mouth.

Supplemental information

• MIXTURE LIST-Contains : Indomethacin

RUO – Research Use Only