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IRAK2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA520163
This item is not returnable.
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Description
This antibody reacts with all four isoforms or IRAK2a. In Western blot applications, this antibody detects a band at ∽65kDa. A suggested positive control is RAW264.7 cell lysate. PA5-20163 can be used with blocking peptide PEP-0280.
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.Specifications
IRAK2 | |
Polyclonal | |
Unconjugated | |
IRAK2 | |
6330415L08Rik; AI649099; interleukin 1 receptor associated kinase 2; interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase 2c; interleukin-1 receptor-associated kinase-like 2; Irak2; IRAK-2; MGC150550; mu-IRAK-2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
108960, 3656 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunocytochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
O43187, Q8CFA1 | |
IRAK2 | |
A peptide corresponding to 17 amino acids near the carboxy terminus of mouse IRAK2a | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |