Isradipine, Tocris Bioscience™

Description

CaV1.x blocker

Potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Specifications

Chemical Identifiers

• CAS: 75695-93-1
• Molecular Formula: C19H21N3O5
• Molecular Weight (g/mol): 371.39
• MDL Number: MFCD00153820
• InChI Key: HMJIYCCIJYRONP-UHFFFAOYNA-N
• Synonym: isradipine, dynacirc, isradipin, lomir, isrodipine, prescal, dynacirc cr, esradin, clivoten, dynacrine
• PubChem CID: 3784
• IUPAC Name: 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• SMILES: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

• Quantity: 10 mg
• Formula Weight: 371.39
• Percent Purity: >99%
• Chemical Name or Material: Isradipine