ISX 9, Tocris Bioscience™

Description

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

ISX 9 is a neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.

ISX 9 synthesized to Ancillary Material Grade also available.

For more information about how ISX 9 may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons .

Specifications

Chemical Identifiers

• CAS: 832115-62-5
• Molecular Formula: C11H10N2O2S
• Molecular Weight (g/mol): 234.273
• InChI Key: SYENTKHGMVKGAQ-UHFFFAOYSA-N
• PubChem CID: 19582717
• IUPAC Name: N-cyclopropyl-5-thiophen-2-yl-1,2-oxazole-3-carboxamide
• SMILES: C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3

• Quantity: 10 mg
• Synonym: isx-9, isx 9, n-cyclopropyl-5-thiophen-2-yl isoxazole-3-carboxamide, isoxazole 9 isx-9, neuronal differentiation inducer iii, n-cyclopropyl-5-thiophen-2-yl-1,2-oxazole-3-carboxamide, isoxazole 9, isx9, isoxazole 9 isx9, n-cyclopropyl-5-2-thienyl-3-isoxazolecarboxamide
• Formula Weight: 234.27
• Percent Purity: >99%
• Chemical Name or Material: ISX 9