ITPA Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA588421

Product Code. 16526671

Description

Immunogen sequence: MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR ALLELQEYFG SLAA; Positive Samples: U-87MG, HT-29, Mouse small intestine, Mouse heart, Rat liver; Cellular Location: Cytoplasm

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Specifications

• Antigen: ITPA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPA
• Gene Alias: 2010016I08Rik, AU020102, C20orf37, dJ794I6.3, HAMAP-Rule:MF_03148}, HLC14-06-P, inosine triphosphatase, inosine triphosphatase (nucleoside triphosphate pyrophosphatase), inosine triphosphatase {ECO:0000255, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphatase {ECO:0000255, inosine triphosphate pyrophosphohydrolase, Itp, ITPA, ITPase, ITPase {ECO:0000255, My049, My049 protein, Non-canonical purine NTP pyrophosphatase, non-canonical purine NTP pyrophosphatase {ECO:0000255, non-standard purine NTP pyrophosphatase, non-standard purine NTP pyrophosphatase {ECO:0000255, NTPase, NTPase {ECO:0000255, nucleoside triphosphate pyrophosphatase, nucleoside-triphosphate diphosphatase, nucleoside-triphosphate diphosphatase {ECO:0000255, Nucleoside-triphosphate pyrophosphatase, nucleoside-triphosphate pyrophosphatase {ECO:0000255, OK/SW-cl.9, Putative oncogene protein hlc14-06-p
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16434, 311422, 3704
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: D3ZW55, Q9BY32, Q9D892
• Gene Symbols: ITPA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human ITPA (NP_2584121)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG