Tocris Bioscience™ Ivosidenib

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Product Code	Brand	Quantity
18736926	Tocris Bioscience™ 7761/10	10 mg
18798656	Tocris Bioscience™ 7761/50	50 mg

Description

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.

Specifications

• Chemical Name or Material: (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• CAS: 1448347-49-6
• Target: Isocitrate Dehydrogenase 1/IDH1
• Molecular Formula: C₂₈H₂₂ClF₃N₆O₃

Safety and Handling

Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.